Lam K S, Hesler G A, Mattei J M, Mamber S W, Forenza S, Tomita K
Bristol-Myers Squibb Company, Pharmaceutical Research and Development Division, Wallingford, Connecticut 06492.
J Antibiot (Tokyo). 1990 Aug;43(8):956-60. doi: 10.7164/antibiotics.43.956.
Strain C39108-P210-51 (ATCC 53653), an actinomycete isolated from a soil sample collected in India, was found to produce a new antitumor antibiotic, designated himastatin. Taxonomic studies on its morphological, cultural and physiological characteristics identified this producing strain as Streptomyces hygroscopicus C39108-P210-51. Himastatin shows antimicrobial activity against Gram-positive bacteria but it is inactive against Gram-negative bacteria. Himastatin prolongs the life span of mice inoculated with P388 leukemia and B16 melanoma cells.
菌株C39108-P210-51（ATCC 53653）是从印度采集的土壤样本中分离出的一种放线菌，被发现能产生一种新的抗肿瘤抗生素，命名为西马他汀。对其形态、培养和生理特征进行的分类学研究确定该产生菌为吸水链霉菌C39108-P210-51。西马他汀对革兰氏阳性菌具有抗菌活性，但对革兰氏阴性菌无活性。西马他汀可延长接种P388白血病和B16黑色素瘤细胞的小鼠的寿命。
