埃坡霉素，一种对B16黑色素瘤有活性的新型抗生素。I. 生产、分离、结构及生物活性。
Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity.
作者信息
Sugawara K, Hatori M, Nishiyama Y, Tomita K, Kamei H, Konishi M, Oki T
机构信息
Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.
出版信息
J Antibiot (Tokyo). 1990 Jan;43(1):8-18. doi: 10.7164/antibiotics.43.8.
PMID:2106503
Abstract
Streptomyces hygroscopicus No. P247-71(ATCC 53709)produced a novel antibiotic eponemycin which exhibited specific in vivo antitumor effect against B16 melanoma. Structural studies assigned (4S)-1,2-epoxy-2-hydroxymethyl-4-(N-isooctanoyl-L- serylamino)-6-methylhept-6-ene-3-one to eponemycin which is unrelated to the known antitumor antibiotics.
摘要
吸水链霉菌No. P247 - 71（ATCC 53709）产生了一种新型抗生素埃坡霉素，该抗生素对B16黑色素瘤具有特异性的体内抗肿瘤作用。结构研究确定埃坡霉素的结构为(4S)-1,2 - 环氧 - 2 - 羟甲基 - 4 - (N - 异辛酰基 - L - 丝氨酰胺基)-6 - 甲基庚 - 6 - 烯 - 3 - 酮，它与已知的抗肿瘤抗生素无关。
Zotero 插件