一些患有与IgM副蛋白血症相关的多发性神经病患者的抗MAG IgM副蛋白也与硫脂发生反应。

Anti-MAG IgM paraproteins from some patients with polyneuropathy associated with IgM paraproteinemia also react with sulfatide.

作者信息

Ilyas A A, Cook S D, Dalakas M C, Mithen F A

机构信息

Department of Neurosciences, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark 07103.

出版信息

J Neuroimmunol. 1992 Mar;37(1-2):85-92. doi: 10.1016/0165-5728(92)90158-h.

DOI:10.1016/0165-5728(92)90158-h

PMID:1372333

Abstract

Sera from five of 11 patients with neuropathy associated with IgM paraproteinemia (NAIgMPP) and reactivity against myelin-associated glycoprotein (MAG) also had elevated levels of IgM against sulfatide. Although three patients had anti-sulfatide IgM titers of less than or equal to 1:1000, two patients had titers of greater than or equal to 1:50,000. Absorption of patient serum with sulfatide revealed that anti-MAG IgM paraproteins in two patients with high titer anti-sulfatide IgM crossreacted with sulfatide. Our study is the first to show that some anti-MAG IgM paraproteins crossreact with sulfatide, a major acidic glycolipid of myelin. Moreover, some patients with NAIgMPP have polyclonal anti-sulfatide IgM in addition to anti-MAG IgM paraproteins. Therefore, sulfatide may be a target antigen in some patients with NAIgMPP.

摘要

11例伴有IgM副蛋白血症的神经病（NAIgMPP）患者中有5例的血清以及针对髓鞘相关糖蛋白（MAG）的反应性，其抗硫脂的IgM水平也升高。虽然3例患者的抗硫脂IgM滴度小于或等于1:1000，但有2例患者的滴度大于或等于1:50,000。用硫脂吸收患者血清显示，2例高滴度抗硫脂IgM患者的抗MAG IgM副蛋白与硫脂发生交叉反应。我们的研究首次表明，一些抗MAG IgM副蛋白与硫脂发生交叉反应，硫脂是髓鞘的一种主要酸性糖脂。此外，一些NAIgMPP患者除了有抗MAG IgM副蛋白外，还有多克隆抗硫脂IgM。因此，硫脂可能是一些NAIgMPP患者的靶抗原。