van den Berg L H, Lankamp C L, de Jager A E, Notermans N C, Sodaar P, Marrink J, de Jong H J, Bär P R, Wokke J H
Department of Neurology, University Hospital Utrecht, The Netherlands.
J Neurol Neurosurg Psychiatry. 1993 Nov;56(11):1164-8. doi: 10.1136/jnnp.56.11.1164.
A study was carried out on 135 patients with chronic idiopathic neuropathy (63), neuropathy associated with monoclonal gammopathy (51, including eight with anti-MAG antibody activity) and the Guillain-Barré syndrome (GBS) (21). Serum IgM, IgG and IgA anti-sulphatide antibody titres were compared with titres in 304 patients with other neurological or immunological diseases and in 50 normal subjects. Titres were presented a) as the highest serum dilution at which reactivity could be detected, and b) in the linear region of the optical density curve. A substantial number of patients with neurological or immunological diseases had higher titres than normal subjects. Compared with normal and disease controls, five patients with neuropathy associated with IgMk monoclonal gammopathy had raised titres of IgM anti-sulphatide antibodies and one patient with GBS had raised IgM, IgG and IgA anti-sulphatide antibodies in the acute phase of the disease. Two patients had a predominantly axonal sensory neuropathy with presenting symptoms of painful paresthesiae and minimal neurological deficit. Three patients had a predominantly demyelinating sensorimotor neuropathy associated with anti-MAG antibody activity. The patient with GBS had extensive sensory loss and antibody titres returned to normal within three weeks. Raised titres of anti-sulphatide antibodies occurred in several types of neuropathy, but all had some degree of sensory impairment and associated immunological abnormality.
对135例慢性特发性神经病患者（63例）、与单克隆丙种球蛋白病相关的神经病患者（51例，包括8例具有抗MAG抗体活性的患者）以及吉兰-巴雷综合征（GBS）患者（21例）进行了一项研究。将血清IgM、IgG和IgA抗硫脂抗体滴度与304例其他神经或免疫疾病患者及50例正常受试者的滴度进行比较。滴度呈现为：a）可检测到反应性的最高血清稀释度；b）在光密度曲线的线性区域。相当数量的神经或免疫疾病患者的滴度高于正常受试者。与正常和疾病对照相比，5例与IgMκ单克隆丙种球蛋白病相关的神经病患者的IgM抗硫脂抗体滴度升高，1例GBS患者在疾病急性期其IgM、IgG和IgA抗硫脂抗体滴度升高。2例患者主要表现为轴索性感觉神经病，症状为疼痛性感觉异常且神经功能缺损轻微。3例患者主要表现为与抗MAG抗体活性相关的脱髓鞘性感觉运动神经病。GBS患者有广泛的感觉丧失，抗体滴度在三周内恢复正常。抗硫脂抗体滴度升高见于几种类型的神经病，但所有患者均有一定程度的感觉障碍及相关免疫异常。
