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Diminished capacity to release metabolites of nitric oxide synthase in macrophages loaded with oxidized low-density lipoproteins.

作者信息

Jorens P G, Rosseneu M, Devreese A M, Bult H, Marescau B, Herman A G

机构信息

Division of Pharmacology, University of Antwerp (UIA), Wilrijk, Belgium.

出版信息

Eur J Pharmacol. 1992 Feb 25;212(1):113-5. doi: 10.1016/0014-2999(92)90082-f.

DOI:10.1016/0014-2999(92)90082-f
PMID:1372867
Abstract

Activation of J774-macrophages with lipopolysaccharide (LPS) or LPS and recombinant interferon-gamma (IFN-gamma) induced nitric oxide (NO) synthase activity, as measured by the production of nitrite and citrulline. NO synthase activity was suppressed by loading the cells with oxidatively modified low-density lipoprotein (ox-LDL) but not with acetylated LDL (ac-LDL), although the intracellular lipid accumulation was comparable. This suggests that the extent of activation of lipid-loaded macrophages may be influenced by the type of lipid.

摘要

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引用本文的文献

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Oxidized lipoproteins suppress nitric oxide synthase in macrophages: study of glucocorticoid receptor involvement.氧化脂蛋白抑制巨噬细胞中的一氧化氮合酶：研究糖皮质激素受体的参与。
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