Kato Y, Kitagawa T, Yanagisawa A, Kubo K, Utsude T, Hiratsuka H, Tamaki M, Sugano H
Department of Pathology, Cancer Institute, Tokyo.
Jpn J Cancer Res. 1992 Feb;83(2):178-83. doi: 10.1111/j.1349-7006.1992.tb00084.x.
The topographical distribution of complete and incomplete types of intestinal metaplasia in human stomach samples was investigated in order to elucidate their mutual histogenetic relationship and significance in carcinogenesis. Subgross stereomicroscopic examination of alcian blue and hematoxylin-stained gastric mucosae allowed clear distinction of complete and incomplete intestinal metaplasia types as white (with or without purple hue) and purple foci, respectively, against the background magenta areas of non-intestinalized mucosa. Intestinal metaplasias which developed in the fundic area were predominantly of the complete type whereas those of the antrum were a mixture of both with a distinct predilection for expression of the incomplete type. Although there was some variation among foci regarding the hue of white or purple, the color feature was principally homogeneous within each individual intestinal metaplasia focus. Thus phenotypic analysis indicated intestinal metaplasia expression to be clearly influenced by intragastric topography. The study did not provide any evidence that a shift from incomplete to complete type intestinal metaplasia may occur with time or that the incomplete type may be more intimately associated with development of well-differentiated carcinomas.
为了阐明人类胃样本中完全型和不完全型肠化生的相互组织发生关系及其在致癌过程中的意义，对其进行了地形分布研究。对经阿尔辛蓝和苏木精染色的胃黏膜进行亚大体立体显微镜检查，可以在未肠化生黏膜的品红色背景区域中，将完全型和不完全型肠化生分别清晰地辨别为白色（有无紫色调）和紫色病灶。发生在胃底区域的肠化生主要是完全型，而胃窦部的肠化生则是两者的混合，且明显倾向于表达不完全型。尽管不同病灶的白色或紫色色调存在一些差异，但在每个单独的肠化生病灶内，颜色特征基本是均匀的。因此，表型分析表明，肠化生的表达明显受胃内地形的影响。该研究没有提供任何证据表明不完全型肠化生可能随时间转变为完全型，也没有表明不完全型与高分化癌的发生有更密切的关系。
