NORTHOVER B J, SUBRAMANIAN G
Br J Pharmacol Chemother. 1961 Aug;17(1):107-15. doi: 10.1111/j.1476-5381.1961.tb01110.x.
The production of kallidin from guinea-pig and ox serum kallidinogen by the action of guinea-pig serum-kallikrein or human salivary kallikrein was inhibited by various analgesic-antipyretic drugs. This effect was obtained in vitro with concentrations of inhibitors which do not inhibit the smooth-muscle-stimulating action of the various polypeptides, but similar to the concentrations needed in vivo to obtain an anti-inflammatory action. The vasodepressor action of intravenously administered human salivary kallikrein in the anaesthetized dog was very markedly inhibited by the intravenous administration of doses of various analgesic-antipyretic drugs which only partially antagonized the responses to kallidin and bradykinin and which left the vasodepressor responses to histamine, acetylcholine and 5-hydroxytryptamine unaffected. In rabbits the accumulation of protein-bound dye at the site of intradermal injection of human salivary kallikrein and guinea-pig serum-kallikrein, but not of bradykinin and kallidin, was inhibited very markedly by the systemic administration of various analgesic-antipyretic drugs.
多种解热镇痛药可抑制豚鼠血清激肽释放酶或人唾液激肽释放酶作用于豚鼠和牛血清激肽原产生胰激肽。这种作用在体外通过抑制剂浓度实现，该浓度不抑制各种多肽的平滑肌刺激作用，但与体内获得抗炎作用所需浓度相似。静脉注射人唾液激肽释放酶对麻醉犬的血管减压作用，被静脉注射多种解热镇痛药剂量显著抑制，这些药物仅部分拮抗对胰激肽和缓激肽的反应，且不影响对组胺、乙酰胆碱和5-羟色胺的血管减压反应。在兔体内，全身给予多种解热镇痛药可非常显著地抑制人唾液激肽释放酶和豚鼠血清激肽释放酶皮内注射部位的蛋白结合染料蓄积，但对缓激肽和胰激肽无此作用。
