Shimada A, Kuwamura M, Awakura T, Umemura T, Takada K, Ohama E, Itakura C
Department of Veterinary Pathology, Faculty of Agriculture, Tottori University, Japan.
J Vet Med Sci. 1992 Feb;54(1):137-44. doi: 10.1292/jvms.54.137.
The distributions of senile plaques (SP) and cerebrovascular amyloidosis (CA) were studied by employing thioflavin S and modified Bielschowsky stains, and beta-protein immunohistochemistry on serial sections of the brains of aged dogs older than 10 years. Mature and perivascular plaques, both of which contained compact amyloid deposits, always showed a close topographic relationship to CA. In contrast, the majority of diffuse plaques showed no topographic relationship to CA. Cell bodies of neurons and/or glia were almost always involved in the diffuse plaques. In addition, beta-protein immunohistochemistry demonstrated amyloid deposits on the periphery of occasional neurons. These findings suggest that different mechanisms may be involved in the development of the different subtypes of SP in the brains of aged dogs.
通过使用硫黄素 S、改良的 Bielschowsky 染色以及β-蛋白免疫组织化学方法，对 10 岁以上老年犬脑的连续切片进行研究，以观察老年斑（SP）和脑血管淀粉样变性（CA）的分布情况。成熟斑和血管周围斑均含有致密的淀粉样沉积物，它们与 CA 始终呈现出紧密的地形学关系。相比之下，大多数弥漫性斑与 CA 无地形学关系。弥漫性斑几乎总是累及神经元和/或胶质细胞的细胞体。此外，β-蛋白免疫组织化学显示偶尔在神经元周边存在淀粉样沉积物。这些发现表明，老年犬脑中不同亚型 SP 的形成可能涉及不同机制。
