Legac E, Autran B, Merle-Beral H, Katlama C, Debre P
Département d'Hématologie, Hôpital Pitié-Salpétrière, Paris, France.
Blood. 1992 Apr 1;79(7):1746-53.
CD7 and CD57 are two cell surface molecules related to the differentiation or functional stages of CD4+ T cells. The CD4+CD7- T cells represent a minor subset of CD4+ cells in normal individuals and are considered to contain the normal counterpart of Sézary T cells; the CD4+CD57+ peripheral blood lymphocytes (PBL) are detectable in long-term renal allograft recipients. We compared the cell surface expression of these CD7 and CD57 markers on CD4+ T lymphocytes in peripheral blood and lymphoid organs from normal individuals and human immunodeficiency virus (HIV)-infected patients. Our results indicate that CD4+CD7- T cells in normal PBL do not express CD57 and were poorly responsive to anti-CD3 monoclonal antibody (MoAb), the activation being restored by addition of anti-CD28 MoAb. This CD4+CD7- cell subset is increased in peripheral blood during HIV infection, and its progressive expansion mirrors both the absolute and relative decrease of CD4+ T cells. The lack of CD7 expression is correlated with CD57 acquisition on CD4+ T cells because CD4+CD7-CD57+ cells represent a major component of the CD4+CD7- subset in HIV-infected patients. Our results suggest that the presence and the expansion of CD4+CD7-CD57+ T lymphocytes, which do not behave as previously defined helper subsets, may participate to the immune dysfunction observed during HIV infection.
CD7和CD57是与CD4+ T细胞分化或功能阶段相关的两种细胞表面分子。CD4+CD7- T细胞是正常个体中CD4+细胞的一个小亚群，被认为包含Sézary T细胞的正常对应物；长期肾移植受者中可检测到CD4+CD57+外周血淋巴细胞（PBL）。我们比较了正常个体和人类免疫缺陷病毒（HIV）感染患者外周血及淋巴器官中CD4+ T淋巴细胞上这些CD7和CD57标志物的细胞表面表达情况。我们的结果表明，正常PBL中的CD4+CD7- T细胞不表达CD57，且对抗CD3单克隆抗体（MoAb）反应较弱，加入抗CD28 MoAb后可恢复其激活。在HIV感染期间，外周血中这一CD4+CD7-细胞亚群会增加，其逐渐扩大反映了CD4+ T细胞绝对数量和相对数量的减少。CD4+ T细胞上CD7表达的缺失与CD57的获得相关，因为CD4+CD7-CD57+细胞是HIV感染患者CD4+CD7-亚群的主要组成部分。我们的结果表明，CD4+CD7-CD57+ T淋巴细胞的存在及扩增，其行为与先前定义的辅助亚群不同，可能参与了HIV感染期间观察到的免疫功能障碍。
