产气荚膜梭菌A型肠毒素功能区域的图谱绘制。
Mapping of functional regions of Clostridium perfringens type A enterotoxin.
作者信息
Hanna P C, Wieckowski E U, Mietzner T A, McClane B A
机构信息
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pennsylvania 15261-2072.
出版信息
Infect Immun. 1992 May;60(5):2110-4. doi: 10.1128/iai.60.5.2110-2114.1992.
Abstract
Studies were conducted to allow construction of an initial map of the structure-versus-function relationship of the Clostridium perfringens type A enterotoxin (CPE). Removal of the N-terminal 25 amino acids of CPE increased the primary cytotoxic effect of CPE but did not affect binding. CPE sequences required for at least four epitopes were also identified.
摘要
开展了多项研究，以构建A型产气荚膜梭菌肠毒素（CPE）结构与功能关系的初步图谱。去除CPE的N端25个氨基酸会增强CPE的主要细胞毒性作用，但不影响其结合。还确定了至少四个表位所需的CPE序列。
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