Zhu W, Dey R D
Department of Anatomy, West Virginia University, Morgantown 26506.
J Mol Cell Cardiol. 1992 Jan;24(1):35-41. doi: 10.1016/0022-2828(92)91157-z.
The neuropeptide galanin (GAL) has been detected in the peripheral and central nervous systems. However, little is known about its distribution and localization in heart, and the possible coexistence of GAL with other neuropeptides in the heart is not established. The present immunocytochemical study describes the distribution of GAL in nerves of the feline heart and its colocalization with vasoactive intestinal peptide (VIP), substance P (SP), and neuropeptide Y (NPY). GAL-like immunoreactivity was widely distributed in the atrial and ventricular myocardium and around coronary arteries. Colocalization of GAL with VIP, SP and NPY was observed in many nerve fibers. Further, GAL and NPY were colocalized in nerve cell bodies of intracardiac ganglia. Since these neuropeptides have been found to be associated with sensory and autonomic innervation in the heart, the present findings provide evidence that GAL is shared by functionally different neuronal populations in the heart and that GAL may participate in controlling cardiac function by combined action with other neuropeptides.
神经肽甘丙肽（GAL）已在周围神经系统和中枢神经系统中被检测到。然而，关于其在心脏中的分布和定位知之甚少，并且GAL与心脏中其他神经肽的可能共存情况尚未明确。目前的免疫细胞化学研究描述了GAL在猫心脏神经中的分布及其与血管活性肠肽（VIP）、P物质（SP）和神经肽Y（NPY）的共定位。甘丙肽样免疫反应广泛分布于心房和心室心肌以及冠状动脉周围。在许多神经纤维中观察到GAL与VIP、SP和NPY的共定位。此外，GAL和NPY在心脏内神经节的神经细胞体中共定位。由于这些神经肽已被发现与心脏的感觉和自主神经支配有关，目前的研究结果提供了证据，表明GAL在心脏中由功能不同的神经元群体共享，并且GAL可能通过与其他神经肽的联合作用参与心脏功能的控制。
