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J Psychiatry Neurosci. 1997 Nov;22(5):303-17.
2
Minireview. Galanin-acetylcholine interactions: relevance to memory and Alzheimer's disease.综述。甘丙肽-乙酰胆碱相互作用：与记忆及阿尔茨海默病的相关性
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Functional interactions of galanin and acetylcholine: relevance to memory and Alzheimer's disease.甘丙肽与乙酰胆碱的功能相互作用：与记忆及阿尔茨海默病的关联
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Galanin expression within the basal forebrain in Alzheimer's disease. Comments on therapeutic potential.阿尔茨海默病患者基底前脑内的甘丙肽表达。关于治疗潜力的评论。
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Galanin plasticity in the cholinergic basal forebrain in Alzheimer's disease and transgenic mice.阿尔茨海默病和转基因小鼠胆碱能基底前脑内的甘丙肽可塑性
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Coadministration of galanin antagonist M40 with a muscarinic M1 agonist improves delayed nonmatching to position choice accuracy in rats with cholinergic lesions.甘丙肽拮抗剂M40与毒蕈碱M1激动剂共同给药可提高胆碱能损伤大鼠的延迟位置匹配错误选择准确性。
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Galanin Regulates Myocardial Mitochondrial ROS Homeostasis and Hypertrophic Remodeling Through GalR2.甘丙肽通过甘丙肽受体2调节心肌线粒体活性氧稳态和肥厚性重塑。
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A 72-hour high fat diet increases transcript levels of the neuropeptide galanin in the dorsal hippocampus of the rat.72小时的高脂饮食会增加大鼠背侧海马体中神经肽甘丙肽的转录水平。
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Deficits in trace cued fear conditioning in galanin-treated rats and galanin-overexpressing transgenic mice.甘丙肽处理的大鼠和甘丙肽过表达转基因小鼠在痕迹线索恐惧条件反射方面存在缺陷。
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Coadministration of galanin antagonist M40 with a muscarinic M1 agonist improves delayed nonmatching to position choice accuracy in rats with cholinergic lesions.甘丙肽拮抗剂M40与毒蕈碱M1激动剂共同给药可提高胆碱能损伤大鼠的延迟位置匹配错误选择准确性。
J Neurosci. 1998 Jul 1;18(13):5078-85. doi: 10.1523/JNEUROSCI.18-13-05078.1998.

本文引用的文献

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Distribution of Galanin mRNA Containing Cells and Galanin Receptor Binding Sites in Human and Rat Hypothalamus.人及大鼠下丘脑内含甘丙肽mRNA的细胞和甘丙肽受体结合位点的分布
Eur J Neurosci. 1990;2(7):629-637. doi: 10.1111/j.1460-9568.1990.tb00452.x.
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Plasticity of galaninergic fibers following neurotoxic damage within the rat basal forebrain: initial observations.大鼠基底前脑神经毒性损伤后甘丙肽能纤维的可塑性：初步观察
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Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors.人和大鼠GALR1受体的药理学特性及组织分布
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A confocal microscopic analysis of galaninergic hyperinnervation of cholinergic basal forebrain neurons in Alzheimer's disease.阿尔茨海默病中胆碱能基底前脑神经元甘丙肽能超神经支配的共聚焦显微镜分析
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Galanin receptors: involvement in feeding, pain, depression and Alzheimer's disease.甘丙肽受体：与进食、疼痛、抑郁及阿尔茨海默病有关。
Life Sci. 1997;60(18):1523-33. doi: 10.1016/s0024-3205(96)00624-8.
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Molecular cloning and characterization of a new receptor for galanin.甘丙肽新受体的分子克隆与特性分析
FEBS Lett. 1997 Apr 1;405(3):285-90. doi: 10.1016/s0014-5793(97)00196-8.
7
125I-galanin binding sites in Alzheimer's disease: increases in hippocampal subfields and a decrease in the caudate nucleus.阿尔茨海默病中125I-甘丙肽结合位点：海马亚区增加，尾状核减少。
J Neurochem. 1997 Mar;68(3):1106-13. doi: 10.1046/j.1471-4159.1997.68031106.x.
8
Galanin receptor antagonist M40 blocks galanin-induced choice accuracy deficits on a delayed-nonmatching-to-position task.甘丙肽受体拮抗剂M40可阻断甘丙肽在延迟位置匹配任务中诱导的选择准确性缺陷。
Behav Neurosci. 1996 Oct;110(5):1025-32. doi: 10.1037//0735-7044.110.5.1025.
9
Effect of estrogen on the expression of galanin mRNA in pituitary tumor-sensitive and tumor-resistant rat strains.雌激素对垂体瘤敏感和抗瘤大鼠品系中甘丙肽mRNA表达的影响。
Steroids. 1996 Aug;61(8):468-72. doi: 10.1016/0039-128x(96)00076-1.
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Animal models of cognitive function.认知功能的动物模型。
Crit Rev Neurobiol. 1995;9(4):321-43.

甘丙肽与乙酰胆碱在啮齿动物记忆任务及阿尔茨海默病中的相互作用。

Galanin-acetylcholine interactions in rodent memory tasks and Alzheimer's disease.

作者信息

McDonald M P, Crawley J N

机构信息

Section on Behavioral Neuropharmacology, National Institute of Mental Health, Bethesda, Md. 20892, USA.

出版信息

J Psychiatry Neurosci. 1997 Nov;22(5):303-17.

PMID:9401311
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1188878/
Abstract

Galanin is a 29-amino-acid neuropeptide that is widely distributed in the mammalian central nervous system. Galanin-immunoreactive cell bodies, fibres and terminals, and galanin binding sites, are located in the basal forebrain of rats, monkeys and humans. Galanin fibres hyperinnervate the surviving cholinergic cell bodies in patients with Alzheimer's disease (AD). In rats, galanin inhibits acetylcholine release and produces deficits in learning and memory. These findings suggest that overexpressed galanin may contribute to the cognitive impairments exhibited by patients with AD. This paper reviews the literature on galanin distribution and function in light of its putative role in the mnemonic deficits in patients with AD, the effects of galanin on tests of learning and memory, and preliminary experiments with galanin antagonists in animal models of AD.

摘要

甘丙肽是一种由29个氨基酸组成的神经肽，广泛分布于哺乳动物的中枢神经系统。甘丙肽免疫反应性细胞体、纤维和终末以及甘丙肽结合位点位于大鼠、猴子和人类的基底前脑。在阿尔茨海默病（AD）患者中，甘丙肽纤维过度支配存活的胆碱能细胞体。在大鼠中，甘丙肽抑制乙酰胆碱释放，并导致学习和记忆缺陷。这些发现表明，过度表达的甘丙肽可能导致AD患者出现认知障碍。本文根据甘丙肽在AD患者记忆缺陷中的假定作用、甘丙肽对学习和记忆测试的影响以及在AD动物模型中使用甘丙肽拮抗剂的初步实验，综述了有关甘丙肽分布和功能的文献。