使用布雷菲德菌素A定位水泡性口炎病毒G蛋白在干扰素处理细胞内的转运阻滞。
Use of Brefeldin A to localize block in intracellular transport of vesicular stomatitis virus G protein on interferon-treated cells.
作者信息
Polakova K, Russ G
机构信息
Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
出版信息
Arch Virol. 1992;124(1-2):171-9. doi: 10.1007/BF01314635.
PMID:1373940
Abstract
Brefeldin A (BFA) induced a rapid redistribution of vesicular stomatitis virus G protein (VSV-G) to the endoplasmatic reticulum (ER) in interferon (IFN)-pretreated cells. This result is consistent with accumulation of VSV-G in the trans-Golgi (GC) complex in cells pretreated with IFN and implies that IFN does not interfere with the ability of BFA to induce redistribution of proteins from GC to ER.
摘要
布雷菲德菌素A（BFA）可诱导水泡性口炎病毒G蛋白（VSV-G）在经干扰素（IFN）预处理的细胞中迅速重新分布至内质网（ER）。这一结果与VSV-G在经IFN预处理的细胞中转高尔基体（GC）复合体中的积累情况一致，意味着IFN并不干扰BFA诱导蛋白质从GC重新分布至ER的能力。
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