Vasta V, Bruni P, Clemente R, Vannini F, Ochoa P, Romero G, Farnararo M, Varela-Nieto I
Dipartimento di Scienze Biochimiche, Università di Firenze, Italy.
Exp Cell Res. 1992 Jun;200(2):439-43. doi: 10.1016/0014-4827(92)90193-c.
The involvement of the glycosylphosphatidylinositol/inositol phosphoglycan (gly-PtdIns/IPG) system in the stimulation of macromolecular syntheses in human fibroblasts has been investigated. The study demonstrates that an insulin sensitive gly-PtdIns/IPG system is present in human fibroblasts, that IPG can significantly stimulate DNA, RNA, and protein synthesis, and that the action of insulin on DNA synthesis as well as that of IPG can be significantly reduced by a specific anti-IPG antibody. These results strongly support the hypothesis that the gly-PtdIns/IPG system is involved in the signal transduction pathway leading to the stimulation of cell proliferation.
糖基磷脂酰肌醇/肌醇磷酸聚糖（gly-PtdIns/IPG）系统在刺激人成纤维细胞中大分子合成方面的作用已得到研究。该研究表明，人成纤维细胞中存在对胰岛素敏感的gly-PtdIns/IPG系统，IPG可显著刺激DNA、RNA和蛋白质合成，并且特定的抗IPG抗体可显著降低胰岛素对DNA合成的作用以及IPG的作用。这些结果有力地支持了以下假说：gly-PtdIns/IPG系统参与了导致细胞增殖受刺激的信号转导途径。
