Varela-Nieto I, León Y, Caro H N
Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
Comp Biochem Physiol B Biochem Mol Biol. 1996 Oct;115(2):223-41. doi: 10.1016/0305-0491(96)00087-9.
The discovery of glycosyl-phosphatidylinositol (GPI) molecules and their products has given new insight into the field of signal transduction. In the last decade a novel mechanism of protein attachment to membranes has emerged, which involves a covalent linkage of the protein to the glycan moiety of a GPI. The discovery that GPI-anchored proteins are ubiquitous throughout the eukaryotes was followed by the observation that uncomplexed GPI molecules are implicated in signal transduction for a diversity of hormones and growth factors. The hydrolysis of free-GPI generates a novel second messenger: the inositol phosphoglycan (IPG). The aim of this article is to review the role of IPG and IPG-like molecules in signal transduction and to discuss future research directions.
糖基磷脂酰肌醇（GPI）分子及其产物的发现为信号转导领域带来了新的见解。在过去十年中，出现了一种蛋白质附着于细胞膜的新机制，该机制涉及蛋白质与GPI聚糖部分的共价连接。GPI锚定蛋白在整个真核生物中普遍存在这一发现之后，又观察到未复合的GPI分子与多种激素和生长因子的信号转导有关。游离GPI的水解产生一种新的第二信使：肌醇磷酸聚糖（IPG）。本文的目的是综述IPG和类IPG分子在信号转导中的作用，并讨论未来的研究方向。
