Behrendt H, Faes J, Ruzicka T
Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München.
Hautarzt. 1992 Mar;43(3):139-42.
Angiolipomas are rare benign tumours of the subcutaneous fat; they are sometimes solitary but their occurrence is more frequently multiple. Angiolipomas can be differentiated from lipomas clinically by their pronounced tenderness and histologically by their variable vascularization. The disease occurs mostly in young adults, the sites of predilection being the trunk and proximal extremities. Multiple angiolipomas have to be differentiated from other lipomatoses, especially from adiposis dolorosa (Dercum's disease). The case reported in this paper was characterized by typical clinical and histological findings. The systemic administration of acetylsalicylic acid, diclofenac, ketotifen, ranitidine, tramadol, tilidine combined with naloxone did not provide adequate pain relief. In contrast, the therapeutic efficiency of the antidepressant doxepin, which also displays antihistaminic effects, suggests a possible role of mediators in the development of pain in angiolipomas.
血管脂肪瘤是皮下脂肪的罕见良性肿瘤；它们有时是单发的，但更常见的是多发。血管脂肪瘤在临床上可通过其明显的压痛与脂肪瘤相鉴别，在组织学上可通过其不同的血管化程度来区分。该病多发生于年轻人，好发部位为躯干和近端肢体。多发性血管脂肪瘤必须与其他脂肪增多症相鉴别，尤其是与痛性肥胖症（德库姆病）相鉴别。本文报道的病例具有典型的临床和组织学表现。全身应用阿司匹林、双氯芬酸、酮替芬、雷尼替丁、曲马多、替利定联合纳洛酮未能充分缓解疼痛。相比之下，具有抗组胺作用的抗抑郁药多塞平的治疗效果表明，介质可能在血管脂肪瘤疼痛的发生中起作用。
