Okrasinski E B, Krahwinkel D J, Sanders W L
Department of Urban Practice, College of Veterinary Medicine, University of Tennessee, Knoxville.
Vet Surg. 1992 Jan-Feb;21(1):20-4. doi: 10.1111/j.1532-950x.1992.tb00006.x.
Under isoflurane anesthesia, 50% of the calculated blood volume was removed from 11 dogs. After 30 minutes, five dogs were treated with hypertonic saline and dextran (HSD) (5 mL/kg) followed by isotonic saline solution (2 mL/kg) intraosseously. Six dogs (controls) received isotonic saline (7 mL/kg) intraosseously. All treatments were administered through the medullary cavity of the tibia over a 30-minute period. Cardiac output, mean arterial pressure, central venous pressure, packed cell volume, total protein, and blood gases were monitored for 4 hours. Cardiac output, mean arterial pressure, and circulating volume (indicated by packed cell volume and total protein) were significantly improved after administration of HSD. We conclude that intraosseous infusion of HSD is efficacious in treating hemorrhagic shock and believe the technique may prove to be useful in clinical situations when intravenous lines cannot be established rapidly.
在异氟烷麻醉下，从11只犬身上抽取计算出血量的50%。30分钟后，5只犬经骨内给予高渗盐水和右旋糖酐（HSD）（5毫升/千克），随后给予等渗盐溶液（2毫升/千克）。6只犬（对照组）经骨内给予等渗盐水（7毫升/千克）。所有治疗均在30分钟内经胫骨骨髓腔给药。监测心输出量、平均动脉压、中心静脉压、血细胞比容、总蛋白和血气4小时。给予HSD后，心输出量、平均动脉压和循环血量（由血细胞比容和总蛋白表示）显著改善。我们得出结论，骨内输注HSD治疗失血性休克有效，并认为该技术在无法迅速建立静脉通路的临床情况下可能有用。
