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Infiltration of helper/inducer T lymphocytes heralds central nervous system damage in human T-cell leukemia virus infection.

作者信息

Iwasaki Y, Ohara Y, Kobayashi I, Akizuki S

机构信息

Department of Neurological Sciences, Tohoku University School of Medicine, Sendai, Japan.

出版信息

Am J Pathol. 1992 May;140(5):1003-8.

PMID:1374584
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1886515/
Abstract

Cellular infiltrates in new and old lesions in two cases of human T-cell leukemia virus associated myelopathy (HAM) were analyzed with anti-CD3 antibody and OPD4 antibody recognizing CD4 + CD45RO + T lymphocytes. A subset of CD4 lymphocytes with helper/inducer function and labeled with OPD4 constitutes up to 65% of CD3 cells in new lesions in the pons and the cervical cord. In contrast, nonhelper cells and macrophages were dominant in long-standing spinal cord lesions of these HAM cases and inflammatory lesions in two cases of Japanese encephalitis. Thus, unlike in viral infections, the central nervous system (CNS) tissue damage associated with human T-cell leukemia virus (HTLV-1) infection appeared to be heralded by the infiltration of helper/inducer T cells.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddc2/1886515/f62f75747b65/amjpathol00089-0009-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddc2/1886515/08854e7da6b4/amjpathol00089-0009-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddc2/1886515/f62f75747b65/amjpathol00089-0009-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddc2/1886515/08854e7da6b4/amjpathol00089-0009-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddc2/1886515/f62f75747b65/amjpathol00089-0009-b.jpg

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本文引用的文献

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Clin Exp Immunol. 1984 Oct;58(1):183-92.
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Multiple sclerosis. Distribution of T cells, T cell subsets and Ia-positive macrophages in lesions of different ages.多发性硬化症。不同年龄病变中T细胞、T细胞亚群及Ia阳性巨噬细胞的分布。
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Effect of Pulsed Methylprednisolone on Pain, in Patients with HTLV-1-Associated Myelopathy.脉冲式甲泼尼龙对人嗜T淋巴细胞病毒1型相关脊髓病患者疼痛的影响。
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