西西里岛东部多次输血的地中海贫血患者中的丙型肝炎病毒和乙型肝炎病毒感染
HCV and HBV infection among multitransfused thalassemics from eastern Sicily.
作者信息
Cacopardo B, Russo R, Fatuzzo F, Cosentino S, Lombardo T, La Rosa R, Celesia B M, Nigro L, Frontini V, Nunnari A
机构信息
Institute of Infectious Diseases, University of Catania, Italy.
出版信息
Infection. 1992 Mar-Apr;20(2):83-5. doi: 10.1007/BF01711069.
Serum specimens from 152 Sicilian multitransfused thalassemic subjects were tested for antibodies to hepatitis C virus (anti- HCV) and for HBV markers by enzyme linked immunoassay and with reference to anti-HCV, confirmed by recombinant immunoblot assay. A high rate (47%) of subjects was anti-HCV positive. HBsAg was found in 8% of patients and 55% had anti-HBs or anti-HBc antibodies or both. Contrary to HBV infection, anti-HCV seropositivity was related to the number of transfused units. The highest anti-HCV prevalence was observed between 16 and 20 years; 100% of persons older than 50 years had at least one marker of HBV infection. In conclusion, HCV and HBV are widespread among multitransfused thalassemic. Probably in our area, particularly during the pre-HBsAg screening era, several multitransfused patients were infected by HBV more readily than by HCV.
对152名接受多次输血的西西里岛地中海贫血患者的血清样本进行了检测，通过酶联免疫吸附测定法检测丙型肝炎病毒抗体（抗-HCV）和乙肝病毒标志物，并参考重组免疫印迹法确认的抗-HCV结果。抗-HCV阳性的患者比例较高（47%）。8%的患者检测到乙肝表面抗原（HBsAg），55%的患者有抗-HBs或抗-HBc抗体或两者皆有。与乙肝病毒感染情况相反，抗-HCV血清阳性与输血单位数量有关。抗-HCV患病率最高的年龄段在16至20岁之间；50岁以上的人群中100%至少有一项乙肝病毒感染标志物。总之，丙型肝炎病毒和乙型肝炎病毒在接受多次输血的地中海贫血患者中广泛传播。在我们地区，可能特别是在乙肝表面抗原筛查前的时期，一些接受多次输血的患者感染乙肝病毒比感染丙型肝炎病毒更容易。
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