Ulrich J
Institut für Pathologie Universität Basel.
Acta Histochem Suppl. 1992;42:11-2.
Senile plaques in the cerebral neocortex, entorhinal cortex and hippocampus are reactive for Acetylcholinesterase (AChE). The same types of plaques are observed, as with immunostains for beta-protein, including the very simple ones, consisting nearly exclusively of loose deposits of beta-protein. If there are many plaques, the normal network of AChE-positive axons disappears. Explanations for both, the apparent shift of AChE from the axons to the plaques on the one hand and the very early development of AChE positive deposits during the plaque development on the other hand are sought.
大脑新皮质、内嗅皮质和海马体中的老年斑对乙酰胆碱酯酶（AChE）呈阳性反应。用β-蛋白免疫染色时可观察到相同类型的斑块，包括非常简单的斑块，几乎完全由β-蛋白的松散沉积物组成。如果有许多斑块，AChE阳性轴突的正常网络就会消失。一方面寻求对AChE从轴突明显转移到斑块的解释，另一方面寻求对斑块形成过程中AChE阳性沉积物非常早期发育的解释。
