Lunsing R J, Hadders-Algra M, Huisjes H J, Touwen B C
Department of Developmental Neurology, University Hospital Groningen, The Netherlands.
Dev Med Child Neurol. 1992 May;34(5):404-9. doi: 10.1111/j.1469-8749.1992.tb11452.x.
To determine whether puberty is related to decreased minor neurological dysfunction (MND), 174 children from the Groningen Perinatal Project who had had MND at nine years were re-examined at 12 years. No signs of MND could be demonstrated in 39 of the children, 33 of whom showed at least three signs of puberty. The presence of minor physical anomalies was associated with persisting MND. The authors hypothesise that puberty is related to a decrease in MND, and discuss the role of hormonal changes in relation to the decrease in minor signs. Re-examination at 14 years will be necessary to confirm this hypothesis, since 68 per cent of the children had not yet reached puberty. Children with MND reached puberty no later than those without.
为了确定青春期是否与轻度神经功能障碍（MND）的减轻有关，对格罗宁根围产期项目中174名9岁时患有MND的儿童在12岁时进行了重新检查。39名儿童未表现出MND迹象，其中33名至少有三个青春期迹象。轻微身体异常的存在与持续性MND相关。作者推测青春期与MND的减轻有关，并讨论了激素变化与轻微体征减轻的关系。由于68%的儿童尚未进入青春期，因此有必要在14岁时进行重新检查以证实这一假设。患有MND的儿童进入青春期的时间不晚于未患MND的儿童。
