Soorani-Lunsing R J
Groningen University Hospital, Department of Obstetrics and Gynaecology, Netherlands.
Early Hum Dev. 1993 Sep;34(1-2):59-67. doi: 10.1016/0378-3782(93)90041-r.
In a follow-up study of the Groningen Perinatal Project (GPP) on minor neurological dysfunction (MND) at 12 and 14 years the onset of puberty appeared to play a role. The children were selected on the presence (n = 185) and absence (n = 185) of MND at 9 years. Puberty was defined by the presence of three or more physical puberty signs. With the onset of puberty the incidence of MND decreased. The neurobehavioral relationships became more explicit after the onset of puberty. All types of MND were related to behavioural and cognitive problems at this developmental stage. In normal children, boys showed an increase of strength during puberty whereas the movements of girls became more fluent. The apparent changes in neurological function during puberty were interpreted as a transformation of the central nervous system. The possible causes are discussed. The conclusion is that gonadal hormones and especially oestrogens, play a role. The fact that two-thirds of the children with MND and behavioural problems outgrow the problems during puberty, can be of great help. Finally, any longitudinal study of brain function, which includes the age of puberty, should pay attention to the pubescent stage.
在格罗宁根围产期项目（GPP）针对12岁和14岁儿童轻微神经功能障碍（MND）的一项随访研究中，青春期的开始似乎起到了一定作用。这些儿童是根据9岁时是否存在MND进行挑选的，其中存在MND的有185名儿童，不存在MND的有185名儿童。青春期由出现三种或更多身体发育迹象来定义。随着青春期的开始，MND的发病率下降。青春期开始后，神经行为关系变得更加明显。在这个发育阶段，所有类型的MND都与行为和认知问题有关。在正常儿童中，男孩在青春期力量增加，而女孩的动作变得更加流畅。青春期神经功能的明显变化被解释为中枢神经系统的一种转变。文中讨论了可能的原因。结论是性腺激素尤其是雌激素起到了作用。三分之二患有MND和行为问题的儿童在青春期过后问题消失，这一事实可能会有很大帮助。最后，任何包含青春期年龄的脑功能纵向研究都应关注青春期阶段。
