Soorani-Lunsing R J, Hadders-Algra M, Huisjes H J, Touwen B C
Department of Developmental Neurology, University Hospital Groningen, Netherlands.
Early Hum Dev. 1993 Apr;33(1):71-80. doi: 10.1016/0378-3782(93)90174-s.
In order to study the hypotheses that puberty is related to a decrease of minor neurological dysfunction (MND) and that persisting MND is associated with perinatal factors, two groups (174 normal, 172 MND) of the Groningen Perinatal Project were followed from 12 to 14 years. At 14 years almost all the children had entered puberty (n = 329) defined as the presence of three or more puberty signs. In the MND group 55% of the children were normal at 14 years and in 45% MND signs were still present, though in a less extensive form. The latter phenomenon was most clear in children who had just begun puberty. The effect of puberty was similar in both sexes. MND which persisted into puberty was related to neonatal neurological deviancy, lower social class, lower obstetrical optimality score and male sex. After differentiation with specific MND clusters, it appeared that fine manipulative disability was associated with neonatal neurological deviancy, with minor physical anomalies and with lower social class; choreiform dyskinesia with asphyxia; hypotonia with constitutionally related factors; and coordination problems with pre-maturity (< 32 weeks).
为了研究青春期与轻微神经功能障碍（MND）减少相关以及持续性MND与围产期因素相关的假说，格罗宁根围产期项目的两组儿童（174名正常儿童、172名MND儿童）从12岁随访至14岁。14岁时，几乎所有儿童都进入了青春期（n = 329），青春期定义为出现三个或更多青春期体征。在MND组中，55%的儿童在14岁时正常，45%的儿童仍有MND体征，不过表现形式较轻。后一种现象在刚开始进入青春期的儿童中最为明显。青春期的影响在男女两性中相似。持续到青春期的MND与新生儿神经异常、社会阶层较低、产科最佳评分较低以及男性性别有关。在对特定的MND集群进行区分后，发现精细操作障碍与新生儿神经异常、轻微身体异常以及社会阶层较低有关；舞蹈样运动障碍与窒息有关；肌张力低下与体质相关因素有关；协调问题与早产（<32周）有关。
