• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

不可逆失活后外周神经中乙酰胆碱酯酶的再生

Acetylcholinesterase regeneration in peripheral nerve after irreversible inactivation.

作者信息

KOENIG E, KOELLE G B

出版信息

Science. 1960 Oct 28;132(3435):1249-50. doi: 10.1126/science.132.3435.1249.

DOI:10.1126/science.132.3435.1249
PMID:13757475
Abstract

The return of acetylcholinesterase activity was studied in several cholinergic structures in the cat after irreversible inactivation by diisopropylfluoro-phosphate. It was found that enzymic activity returned uniformly along the hypoglossal and cervical sympathetic nerve trunks. No evidence for somatoaxonal convection of enzyme was obtained.

摘要

在猫体内，通过二异丙基氟磷酸使其不可逆失活后，研究了几种胆碱能结构中乙酰胆碱酯酶活性的恢复情况。结果发现，酶活性沿舌下神经和颈交感神经干均匀恢复。未获得酶体轴突对流的证据。

相似文献

1
Acetylcholinesterase regeneration in peripheral nerve after irreversible inactivation.不可逆失活后外周神经中乙酰胆碱酯酶的再生
Science. 1960 Oct 28;132(3435):1249-50. doi: 10.1126/science.132.3435.1249.
2
Decrease of acetylcholinesterase activity along peripheral nerves.外周神经中乙酰胆碱酯酶活性降低。
Science. 1962 Feb 2;135(3501):368-70. doi: 10.1126/science.135.3501.368.
3
The distribution of cholinesterases in the cat carotid body.胆碱酯酶在猫颈动脉体中的分布。
J Physiol. 1966 Mar;183(2):501-12. doi: 10.1113/jphysiol.1966.sp007880.
4
Selective, near-total, irreversible inactivation of peripheral pseudocholinesterase and acetylcholinesterase in cats in vivo.猫体内外周假性胆碱酯酶和乙酰胆碱酯酶的选择性、近乎完全、不可逆失活。
Biochem Pharmacol. 1974 Jan 15;23(2):175-88. doi: 10.1016/0006-2952(74)90408-0.
5
Effects of aldehyde fixation and of preganglionic denervation on acetylcholinesterase and butyrocholinesterase of cat autonomic ganglia.醛固定和节前神经去支配对猫自主神经节乙酰胆碱酯酶和丁酰胆碱酯酶的影响。
J Histochem Cytochem. 1974 Apr;22(4):244-51. doi: 10.1177/22.4.244.
6
Interrelationships between ganglionic acetylcholinesterase and nonspecific cholinesterase of the cat and rat.猫和大鼠神经节乙酰胆碱酯酶与非特异性胆碱酯酶之间的相互关系。
Proc Natl Acad Sci U S A. 1979 Nov;76(11):6012-6. doi: 10.1073/pnas.76.11.6012.
7
[Relations between cholinergic receptors and acetylcholinesterase of the end-plates, examined during the degeneration and regeneration of the mouse diaphragm].
Helv Physiol Pharmacol Acta. 1961;19:119-34.
8
The regeneration of cholinesterase-positive structures in the process of burn wound healing in the skin of the guinea-pig.豚鼠皮肤烧伤创面愈合过程中胆碱酯酶阳性结构的再生
Burns Incl Therm Inj. 1982 Nov;9(2):121-7. doi: 10.1016/0305-4179(82)90060-2.
9
Regeneration of ventral root axons into dorsal roots as shown by increased acetylcholinesterase activity.
J Neurobiol. 1972;3(3):245-57. doi: 10.1002/neu.480030307.
10
Innervation of syngeneic vein grafts in the rat. The regeneration of cholinesterase positive nerves.大鼠同种异体静脉移植物的神经支配。胆碱酯酶阳性神经的再生。
Scand J Plast Reconstr Surg. 1984;18(2):181-5. doi: 10.3109/02844318409052835.

引用本文的文献

1
Local Translation in Nervous System Pathologies.神经系统疾病中的局部翻译
Front Integr Neurosci. 2021 Jun 29;15:689208. doi: 10.3389/fnint.2021.689208. eCollection 2021.
2
Functional Genomics of Axons and Synapses to Understand Neurodegenerative Diseases.轴突与突触的功能基因组学以理解神经退行性疾病
Front Cell Neurosci. 2021 Jun 25;15:686722. doi: 10.3389/fncel.2021.686722. eCollection 2021.
3
Intra-axonal protein synthesis in development and beyond.发育及其他阶段的轴突内蛋白质合成
Int J Dev Neurosci. 2016 Dec;55:140-149. doi: 10.1016/j.ijdevneu.2016.03.004. Epub 2016 Mar 9.
4
Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair.轴突 mRNA 定位与局部蛋白质合成在神经系统组装、维持和修复中的作用。
Nat Rev Neurosci. 2012 Apr 13;13(5):308-24. doi: 10.1038/nrn3210.
5
Local translation and mRNA trafficking in axon pathfinding.轴突导向中的局部翻译与mRNA运输
Results Probl Cell Differ. 2009;48:269-88. doi: 10.1007/400_2009_5.
6
A comparative study of the somato-axonal flow of protein in the feline hypoglossal and vagus nerves.猫舌下神经和迷走神经中蛋白质躯体轴突运输的比较研究。
Exp Brain Res. 1969;8(2):150-62. doi: 10.1007/BF00234536.
7
[Autoradiographic studies on the RNA metabolism in the optic tectum of Brachydanio rerio Ham. Buch. (Cyprinidae, Pisces)].[关于斑马鱼（鲤科，硬骨鱼纲）视顶盖RNA代谢的放射自显影研究]
Histochemie. 1967;11(3):205-15. doi: 10.1007/BF00306369.
8
Migration of axonal protein: absence of a protein concentration gradient and effect of inhibition of protein synthesis.轴突蛋白的迁移：蛋白质浓度梯度的缺失及蛋白质合成抑制的影响
Exp Brain Res. 1967;4(2):138-45. doi: 10.1007/BF00240359.