Skalova A, Leivo I
Department of Pathology, University of Helsinki, Finland.
Virchows Arch A Pathol Anat Histopathol. 1992;420(5):425-31. doi: 10.1007/BF01600514.
Immunohistochemical localization of type IV collagen and laminin in normal salivary glands and in salivary gland tumours of various types was studied using rabbit antisera. In normal salivary glands, type IV collagen and laminin were co-localized in basement membranes surrounding acini, ducts, fat cells and peripheral nerves. In salivary gland tumours, three main patterns of co-expression of these basement membrane proteins were distinguished. Linear basement membrane-like staining was detected in duct-cell-derived benign salivary gland tumours and in acinic cell carcinomas. In invasive lesions, however, these basement membrane proteins were distributed in an irregular, interrupted manner, and in many cases they were completely absent. Both benign and malignant salivary gland tumours which have a prominent myoepithelial cell component display a particular deposition of basement membrane molecules adjacent to the modified myoepithelial cells, and at the margins of extracellular matrix deposits within these tumours.
使用兔抗血清研究了IV型胶原和层粘连蛋白在正常唾液腺及各种类型唾液腺肿瘤中的免疫组织化学定位。在正常唾液腺中，IV型胶原和层粘连蛋白共定位于腺泡、导管、脂肪细胞和周围神经周围的基底膜中。在唾液腺肿瘤中，区分出了这些基底膜蛋白共表达的三种主要模式。在导管细胞来源的良性唾液腺肿瘤和腺泡细胞癌中检测到线性基底膜样染色。然而，在浸润性病变中，这些基底膜蛋白呈不规则、间断分布，且在许多情况下完全缺失。具有显著肌上皮细胞成分的良性和恶性唾液腺肿瘤，在修饰的肌上皮细胞附近以及这些肿瘤内细胞外基质沉积物的边缘均显示出基底膜分子的特殊沉积。
