Skalova A, Leivo I
Department of Pathology, University of Helsinki, Finland.
Arch Pathol Lab Med. 1992 Jun;116(6):649-53.
Collagenous spherulosis is a benign breast lesion involving lobular acini and ductules and containing eosinophilic spherules measuring up to 100 microns in diameter. We present an immunohistochemical analysis of similar collagen-rich spherules that are also found in salivary gland tumors. These collagenous spherules contain varying amounts of acidic mucins, elastin, basement membrane proteins including type IV collagen and laminin, and considerable amounts of interstitial collagen types I and III. Types II and VI collagen were not detected in collagenous spherules of salivary gland tumors. The cells surrounding these collagenous spherules expressed muscle actin, S100 protein, vimentin, and cytokeratins 8, 18, and 19, indicating that these cells have myoepithelial characteristics.
胶原球病是一种良性乳腺病变，累及小叶腺泡和小导管，含有直径达100微米的嗜酸性小球。我们对唾液腺肿瘤中也发现的类似富含胶原的小球进行了免疫组织化学分析。这些胶原小球含有不同量的酸性粘蛋白、弹性蛋白、包括IV型胶原和层粘连蛋白在内的基底膜蛋白，以及大量的I型和III型间质胶原。在唾液腺肿瘤的胶原小球中未检测到II型和VI型胶原。围绕这些胶原小球的细胞表达肌动蛋白、S100蛋白、波形蛋白以及细胞角蛋白8、18和19，表明这些细胞具有肌上皮特征。
