作为氨酰化作用底物的小RNA螺旋及其与转运RNA负载的关系。

Small RNA helices as substrates for aminoacylation and their relationship to charging of transfer RNAs.

作者信息

Francklyn C, Musier-Forsyth K, Schimmel P

机构信息

Department of Biochemistry, University of Vermont College of Medicine, Burlington.

出版信息

Eur J Biochem. 1992 Jun 1;206(2):315-21. doi: 10.1111/j.1432-1033.1992.tb16929.x.

DOI:10.1111/j.1432-1033.1992.tb16929.x

PMID:1375910

Abstract

RNA microhelices that reconstruct the acceptor stems of transfer RNAs can be aminoacylated. The anticodon-independent aminoacylation is sequence-specific and suggests a relationship between amino acids and nucleotide sequences which is different from that of the classical genetic code. The specific aminoacylation of RNA microhelices also suggests a highly differentiated adaptation of the structures of aminoacyl-tRNA synthetases to sequences in the acceptor stems of transfer RNAs.

摘要

能够重建转运RNA接受茎的RNA微螺旋可以被氨酰化。不依赖反密码子的氨酰化具有序列特异性，这表明氨基酸与核苷酸序列之间的关系不同于经典遗传密码中的关系。RNA微螺旋的特异性氨酰化还表明氨酰-tRNA合成酶的结构对转运RNA接受茎中的序列具有高度分化的适应性。