Wechsler J, Fromont G, André J M, Zafrani E S
Department of cells & Tissue Pathology, Henri Mondor Hospital, Créteil, France.
J Cutan Pathol. 1992 Apr;19(2):142-4. doi: 10.1111/j.1600-0560.1992.tb01356.x.
Cutaneous lymphadenoma of the eyebrow occurred in a 72-year-old man. The nodular tumor was well circumscribed but non encapsulated and invaded the reticular dermis and superficial hypodermis without any connection with the epidermis. Tumor cells had a basal-like appearance and were arranged in small lobules and islands with peripheral palisading and areas of central keratinization. They were often dissociated by an extracellular mucinous material. The stroma was fibroblastic and contained a marked lymphoid infiltrate that surrounded and penetrated the neoplastic lobules. Occasional germ-like hair follicle structures were noted. The immunohistochemical pattern was similar to that of hair follicles, and the leucocytic component was predominantly composed of T-lymphocytes and Langerhans cells, which were specially numerous within the neoplastic lobules. We believe that the tumor, in the present case, has morphologic features consistent with epithelial and stromal attributes observed in hair follicles.
一名72岁男性发生了眉部皮肤淋巴结瘤。结节状肿瘤边界清楚但无包膜，侵犯网状真皮和浅表皮下组织，与表皮无任何连接。肿瘤细胞呈基底样外观，排列成小叶和岛状，周边呈栅栏状排列，中央有角化区域。它们常被细胞外黏液物质分隔。间质为成纤维细胞性，有明显的淋巴细胞浸润，围绕并穿透肿瘤小叶。可见偶尔的胚样毛囊结构。免疫组化模式与毛囊相似，白细胞成分主要由T淋巴细胞和朗格汉斯细胞组成，在肿瘤小叶内特别多。我们认为，在本病例中，肿瘤具有与毛囊中观察到的上皮和间质特征一致的形态学特征。
