Abdullaev F I, Frenkel G D
Laboratory of Genome Biochemistry, Institute of Botany, Baku, Azerbaijan, USSR.
Biofactors. 1992 Jan;3(3):201-4.
A concentrated extract of saffron was prepared from the flowers of Crocus sativis. The effect of this extract on the ability of HeLa cells to form colonies, and on cellular DNA, RNA and protein synthesis was examined. Incubation of cells with extract for 3 h resulted in significant inhibition of colony formation and cellular nucleic acid synthesis with 50% inhibition at concentrations of approximately 100-150 micrograms/ml. In contrast there was no inhibition of cellular protein synthesis at concentrations of extract as high as 400 micrograms/ml.
从藏红花的花朵中制备了一种藏红花浓缩提取物。研究了该提取物对HeLa细胞形成集落的能力以及对细胞DNA、RNA和蛋白质合成的影响。用提取物孵育细胞3小时导致集落形成和细胞核酸合成受到显著抑制，在浓度约为100 - 150微克/毫升时抑制率达50%。相比之下，在提取物浓度高达400微克/毫升时，细胞蛋白质合成未受到抑制。
