Abdullaev F I, Frenkel G D
Laboratory of Genome Biochemistry, Institute of Botany, Baku, Azerbaijan.
Biofactors. 1992 Dec;4(1):43-5.
Extract of saffron (Crocus sativis) has previously been shown to inhibit colony formation and cellular DNA and RNA synthesis by HeLa cells in vitro. In order to compare the sensitivity of malignant and non-malignant cells to saffron, we examined the effect of the extract on macromolecular synthesis in three human cell lines: A549 cells (derived from a lung tumor), WI-38 cells (normal lung fibroblasts) and VA-13 cells (WI-38 cells transformed in vitro by SV40 tumor virus). We found that the malignant cells were more sensitive than the normal cells to the inhibitory effects of saffron on both DNA and RNA synthesis. There was no effect on protein synthesis in any of the cells.
此前研究表明，藏红花（番红花）提取物在体外可抑制HeLa细胞的集落形成以及细胞DNA和RNA合成。为比较恶性细胞和非恶性细胞对藏红花的敏感性，我们检测了该提取物对三种人类细胞系大分子合成的影响：A549细胞（源自肺肿瘤）、WI-38细胞（正常肺成纤维细胞）和VA-13细胞（经SV40肿瘤病毒体外转化的WI-38细胞）。我们发现，在藏红花对DNA和RNA合成的抑制作用方面，恶性细胞比正常细胞更敏感。对任何一种细胞的蛋白质合成均无影响。
