在啮齿动物中筛选化学预防（抗癌）化合物。

Screening for chemopreventive (anticarcinogenic) compounds in rodents.

作者信息

Boone C W, Steele V E, Kelloff G J

机构信息

Chemoprevention Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

出版信息

Mutat Res. 1992 Jun;267(2):251-5. doi: 10.1016/0027-5107(92)90069-e.

DOI:10.1016/0027-5107(92)90069-e

PMID:1376427

Abstract

The Chemoprevention Branch is testing dozens of candidate chemopreventive compounds in the following rodent model carcinogenesis systems: mouse skin papillomas, DMBA/TPA induced, rat mammary adenocarcinoma, DMBA and MNU induced, hamster tracheal squamous cell carcinoma, MNU induced, and lung adenocarcinoma, DEN induced, rat and mouse colon adenocarcinoma, AOM and MAM acetate induced, respectively, and mouse bladder carcinoma, hydroxy BBN induced. Significant chemopreventive (i.e., anticancer) effects have been produced with 4-hydroxy-phenylretinamide, difluoromethylornithine, piroxicam, oltipraz (a dithiolthione), calcium glucarate, N-acetylcysteine, beta-carotene, ibuprofen, dehydroepiandrosterone (DHEA) and a 16-fluoro DHEA analog, 8354, tamoxifen, glycyrrhetinic acid, molybdate, selenite, curcumin, and fumaric acid.

摘要

化学预防科正在以下啮齿动物模型致癌系统中测试数十种化学预防候选化合物

二甲基苯并蒽/十四酰佛波醇-12-肉豆蔻酸酯-13-乙酸酯诱导的小鼠皮肤乳头瘤、二甲基苯并蒽和N-甲基-N-亚硝基脲诱导的大鼠乳腺腺癌、N-甲基-N-亚硝基脲诱导的仓鼠气管鳞状细胞癌、二乙基亚硝胺诱导的肺腺癌、分别由氧化偶氮甲烷和乙酸甲酯诱导的大鼠和小鼠结肠腺癌，以及羟基丁基苄基硝胺诱导的小鼠膀胱癌。4-羟基苯基视黄酰胺、二氟甲基鸟氨酸、吡罗昔康、奥替普拉（一种二硫代硫酮）、葡萄糖醛酸钙、N-乙酰半胱氨酸、β-胡萝卜素、布洛芬、脱氢表雄酮（DHEA）及其16-氟DHEA类似物8354、他莫昔芬、甘草次酸、钼酸盐、亚硒酸盐、姜黄素和富马酸已产生显著的化学预防（即抗癌）效果。