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Biozzi小鼠对胶原诱导性关节炎的抗性与针对软骨胶原上可及表位的自身抗体缺陷无关。

Resistance to collagen-induced arthritis in Biozzi mice is not associated with a defect in autoantibodies to accessible epitopes on cartilage collagen.

作者信息

Bouvet J P, Franc B, Zyad A, Couderc J

机构信息

Unité d'Immunologie Microbienne, Institut Pasteur, Paris, France.

出版信息

Scand J Immunol. 1992 Jun;35(6):677-80. doi: 10.1111/j.1365-3083.1992.tb02974.x.

DOI:10.1111/j.1365-3083.1992.tb02974.x
PMID:1376490
Abstract

In order to understand why most strains of Biozzi mice are unexpectedly either arthritis-resistant, or susceptible, we investigate the autoantibody reactivity against matrix-embedded collagen molecules. We show a close correlation between these tissular and the free collagen antibodies, irrespective of arthritis susceptibility. These results are against an antibody response restricted to hidden non-pathogenic epitopes in the resistant mice.

摘要

为了理解为什么大多数Biozzi小鼠品系要么意外地具有抗关节炎能力，要么易患关节炎，我们研究了针对基质包埋胶原分子的自身抗体反应性。我们发现，无论关节炎易感性如何，这些组织抗体与游离胶原抗体之间都存在密切相关性。这些结果与抗性小鼠中仅针对隐藏的非致病性表位的抗体反应相悖。

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