Fassbender K, Michels H, Vogt P, Aeschlimann A, Müller W
Department of Rheumatology, University Hospital, Felix-Platter-Spital, Basel, Switzerland.
Scand J Rheumatol. 1992;21(3):120-3. doi: 10.3109/03009749209095082.
Concentrations of interleukin-2 receptors were studied in sera of 81 patients with pauciarticular-, polyarticular-, and systemic-onset juvenile chronic arthritis using a double antibody "sandwich" enzyme-linked immunosorbent technique. Serum concentrations were significantly increased in all subgroups when compared with the healthy controls. Higher concentrations were found in systemic onset disease than in pauci- or polyarticular onset disease. Serum levels were found to be increased in both inactive and active disease, showing maximal values in patients with systemic features. A correlation to C-reactive protein, alpha 1-acid glycoprotein, and erythrocyte sedimentation was observed. Increased sIL-2R values suggest disease activity despite the absence of clinical symptoms.
采用双抗体“夹心”酶联免疫吸附技术，对81例少关节型、多关节型和全身型幼年慢性关节炎患者血清中的白细胞介素-2受体浓度进行了研究。与健康对照组相比，所有亚组的血清浓度均显著升高。全身型疾病患者的浓度高于少关节型或多关节型疾病患者。在疾病静止期和活动期，血清水平均升高，在有全身症状的患者中达到最大值。观察到与C反应蛋白、α1-酸性糖蛋白和红细胞沉降率存在相关性。尽管没有临床症状，但可溶性白细胞介素-2受体值升高提示疾病活动。
