Varesco L, Caligo M A, Simi P, Black D M, Nardini V, Casarino L, Rocchi M, Ferrara G, Solomon E, Bevilacqua G
Institute of Pathological Anatomy and Histology, University of Pisa, Italy.
Genes Chromosomes Cancer. 1992 Jan;4(1):84-8. doi: 10.1002/gcc.2870040113.
The NM23-Hl gene is a putative tumor suppressor gene that may be important in the metastasic process. Recent genetic and immunological data indicate that the NM23-Hl gene encodes a protein with nucleoside diphosphate (NDP) kinase activity. The mapping of NM23-Hl by panels of rodent-human somatic cell hybrids and in situ hybridization showed that the gene is located in human chromosome band 17q22. A two-allele polymorphism with BglII was demonstrated.
NM23-Hl基因是一种推测的肿瘤抑制基因，可能在转移过程中起重要作用。最近的遗传学和免疫学数据表明，NM23-Hl基因编码一种具有核苷二磷酸（NDP）激酶活性的蛋白质。通过啮齿动物-人类体细胞杂交组和原位杂交对NM23-Hl进行定位，结果显示该基因位于人类染色体17q22带。已证实存在BglII双等位基因多态性。
