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包含家族性乳腺癌基因座（BRCA1）的人类17号染色体长臂的体细胞杂交图谱。

A somatic cell hybrid map of the long arm of human chromosome 17, containing the familial breast cancer locus (BRCA1).

作者信息

Black D M, Nicolai H, Borrow J, Solomon E

机构信息

Somatic Cell Genetics Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, England.

出版信息

Am J Hum Genet. 1993 Apr;52(4):702-10.

PMID:8460635
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1682064/
Abstract

We describe a detailed somatic cell hybrid map of human chromosome 17q11.2-q23, containing the familial breast and ovarian cancer locus (BRCA1) and highly informative closely linked markers. An X-irradiation panel of 38 hamster/human and mouse/human hybrids with fragments of chromosome 17 was generated and characterized with 22 STS markers from this chromosome. A detailed map of 61 probes onto chromosome 17q, subdividing the chromosome arm into 25 regions, was done by using a panel of hybrids with well-defined breakpoints and nine chromosome-mediated gene transfectants. Our localization of RARA, TOP2, EDH17B1 and 2, and possibly WNT3, between THRA1 and D17S181, two markers known to flank BRCA1, suggests that any of these is a potential candidate for the BRCA1 locus. The marker D17S579 (Mfd188), which is believed to be very close to BRCA1, maps closest to the EDH17B genes.

摘要

我们描述了人类17号染色体q11.2 - q23的详细体细胞杂交图谱，其中包含家族性乳腺癌和卵巢癌基因座（BRCA1）以及信息丰富的紧密连锁标记。构建了一个由38个携带17号染色体片段的仓鼠/人类和小鼠/人类杂交体组成的X射线照射面板，并用来自该染色体的22个STS标记对其进行了特征分析。通过使用一组具有明确断点的杂交体和9个染色体介导的基因转染体，完成了61个探针在17号染色体q上的详细图谱，将染色体臂细分为25个区域。我们将RARA、TOP2、EDH17B1和2以及可能的WNT3定位在已知位于BRCA1两侧的两个标记THRA1和D17S181之间，这表明这些基因中的任何一个都是BRCA1基因座的潜在候选基因。标记D17S579（Mfd188）被认为与BRCA1非常接近，其定位最靠近EDH17B基因。

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Am J Hum Genet. 1993 Apr;52(4):702-10.
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本文引用的文献

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Integration of Ecogpt and SV40 early region sequences into human chromosome 17: a dominant selection system in whole cell and microcell human-mouse hybrids.Ecogpt与SV40早期区域序列整合到人17号染色体中：全细胞和微细胞人-鼠杂种中的显性选择系统。
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THRA1 and D17S183 flank an interval of < 4 cM for the breast-ovarian cancer gene (BRCA1) on chromosome 17q21.THRA1和D17S183位于17号染色体q21区域的乳腺癌-卵巢癌基因（BRCA1）两侧，间隔小于4厘摩。
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The nerve growth factor receptor gene is at human chromosome region 17q12-17q22, distal to the chromosome 17 breakpoint in acute leukemias.神经生长因子受体基因位于人类染色体区域17q12 - 17q22，在急性白血病中位于17号染色体断裂点的远端。
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Proc Natl Acad Sci U S A. 1989 Aug;86(16):6211-4. doi: 10.1073/pnas.86.16.6211.

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