利用来自染色体17q11-q24区域的高度多态性标记，对德国早发性乳腺癌家族进行连锁分析。
Linkage analysis in German breast cancer families with early onset of the disease, using highly polymorphic markers from the chromosome 17q11-q24 region.
作者信息
Zimmermann W, Bender E, Rohde K, Reis A, Wiseman R, Futreal A, Krause H, Prokoph H, Werner S, Scherneck S
机构信息
Tumorgenetik, Max-Delbrück-Centrum für Molekulare Medizin, Berlin-Buch, Germany.
出版信息
Am J Hum Genet. 1993 Apr;52(4):789-91.
Abstract
Linkage analysis in German breast cancer families with early onset of the disease by using six markers on chromosome 17q11-q24 has been carried out. In the region between markers D17S250 and GH, three markers showed positive LOD scores at an estimated distance of zero. Evidence for linkage is greatest for D17S250, with a LOD score of 2.42.
摘要
通过使用位于17号染色体q11 - q24区域的六个标记，对德国早发性乳腺癌家族进行了连锁分析。在标记D17S250和GH之间的区域，三个标记在估计距离为零处显示出正的LOD分数。D17S250的连锁证据最强，LOD分数为2.42。
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