Nojima T, Kojima T, Kato H, Sato T, Koito K, Nagashima K
Department of Pathology, Hokkaido University School of Medicine, Sapporo, Japan.
Hum Pathol. 1992 Jul;23(7):828-30. doi: 10.1016/0046-8177(92)90354-6.
A pancreatic carcinoma and liver metastases associated with marked elevation of the serum alpha-fetoprotein (AFP) level were resected from a 57-year-old man. On microscopic examination, the tumor cells showed a predominantly acinar arrangement, with tubular and trabecular structures; in some foci it had features of a medullary pattern. Alpha-fetoprotein, lipase, trypsin, chymotrypsin, and alpha 1-antitrypsin were strongly demonstrated in tumor tissue by immunohistochemical techniques. A biochemical analysis of AFP on affinity sepharose columns revealed that the AFP derived from the tumor tissues was similar to that of hepatocellular carcinoma. Ultrastructural study showed that most of the tumor cells had abundant rough endoplastic reticulum and numerous zymogen granules. No squamoid corpuscles, neuroendocrine granules, bile production, or bile canaliculi were recognized. These findings suggest that this unique tumor originated from acinar cells.
从一名57岁男性患者身上切除了伴有血清甲胎蛋白（AFP）水平显著升高的胰腺癌及肝转移瘤。显微镜检查显示，肿瘤细胞主要呈腺泡状排列，伴有管状和小梁状结构；在一些病灶中具有髓样模式的特征。通过免疫组化技术在肿瘤组织中强烈显示出甲胎蛋白、脂肪酶、胰蛋白酶、糜蛋白酶和α1-抗胰蛋白酶。对亲和琼脂糖柱上的AFP进行生化分析表明，肿瘤组织来源的AFP与肝细胞癌的相似。超微结构研究显示，大多数肿瘤细胞具有丰富的粗面内质网和大量酶原颗粒。未发现鳞状小体、神经内分泌颗粒、胆汁生成或胆小管。这些发现提示这种独特的肿瘤起源于腺泡细胞。
