Shinagawa T, Tadokoro M, Maeyama S, Maeda C, Yamaguchi S, Morohoshi T, Ishikawa E
Department of Pathology, St. Marianna University School of Medicine, Yokohama City/Seibu Hospital, Japan.
Virchows Arch. 1995;426(4):419-23. doi: 10.1007/BF00191352.
An alpha fetoprotein (AFP)-producing tumour occurring in the head of the pancreas of a 30-year-old woman is reported. Histological examination revealed a markedly solid proliferation of tumour cells with prominent nucleoli and occasional luminal structures, some of which contained mucinous material stained with mucicarmine and alcian blue. No squamoid corpuscles were recognized. Immunohistochemistry showed intense positivity for lipase trypsin, and AFP basically, and single cells were also positive for carcino-embryonic antigen, CA19-9, synaptophysin and neuron-specific enolase. Pancreatic hormone-positive cells were absent. Electron microscopical examination revealed numerous granules of variable sizes in the tumour cells, which were considered to be zymogen. The tumour is an acinar cell carcinoma with multi-directional differentiation including the ability to produce AFP. Among AFP-positive pancreatic tumours, acinar cell carcinoma and pancreatoblastoma seem to be the most frequent.
报告了一名30岁女性胰腺头部发生的产生甲胎蛋白（AFP）的肿瘤。组织学检查显示肿瘤细胞明显呈实性增殖，核仁突出，偶尔可见管腔结构，其中一些含有经黏液卡红和阿尔辛蓝染色的黏液物质。未发现鳞状小体。免疫组织化学显示脂肪酶、胰蛋白酶和AFP基本呈强阳性，单个细胞癌胚抗原、CA19-9、突触素和神经元特异性烯醇化酶也呈阳性。未发现胰腺激素阳性细胞。电子显微镜检查显示肿瘤细胞内有许多大小不一的颗粒，被认为是酶原颗粒。该肿瘤是一种具有多向分化能力（包括产生AFP能力）的腺泡细胞癌。在AFP阳性的胰腺肿瘤中，腺泡细胞癌和胰腺母细胞瘤似乎最为常见。
