Sasiadek M
Medical Academy, Department of Pathophysiology, Wrocław, Poland.
Mutat Res. 1992 Jun 1;279(3):195-8. doi: 10.1016/0165-1218(92)90066-9.
Lymphocytes from 21 vulcanizers from a tire factory were analyzed for the presence of chromosome aberrations (CAs), sister-chromatid exchanges (SCEs) and for proliferation indices (PIs). An increase in the frequencies of CAs and SCEs and a decrease in PIs were observed. Cytogenetic parameters were correlated with age, smoking habits, and duration of occupational exposure. From the present study it can be concluded that cigarette smoking enhances the genotoxic effects of mixtures of chemicals to which workers in the rubber industry are exposed.
对一家轮胎厂21名硫化工人的淋巴细胞进行分析，以检测染色体畸变（CA）、姐妹染色单体交换（SCE）的存在情况以及增殖指数（PI）。结果观察到CA和SCE频率增加，PI降低。细胞遗传学参数与年龄、吸烟习惯和职业接触时长相关。从本研究可以得出结论，吸烟会增强橡胶行业工人所接触化学物质混合物的遗传毒性作用。
