Martin F, Earl R, Tawn E J
Geoffrey Schofield Cytogenetics Laboratory, British Nuclear Fuels Plc-Sell-field-Seascale, Cumbria.
Br J Ind Med. 1991 Feb;48(2):98-102. doi: 10.1136/oem.48.2.98.
Blood lymphocyte cultures from two groups of workers occupationally exposed to uranium were examined for asymmetrical chromosome aberrations and sister chromatid exchanges (SCEs). Significant increases in both cytogenetic endpoints were seen. For dicentrics this appeared to be particularly associated with exposure to soluble uranium. The external radiation exposure experienced by these men was insufficient to explain the increase in dicentrics, and irradiation of lymphocytes by internally deposited uranium would have been minimal. As the SCEs were also raised, the genotoxic effect is likely to be due to the chemical nature of the compound. The increase in frequency of dicentrics associated with smoking was greatest in the group with exposure to soluble uranium suggesting some interaction between the two clastogens. No such interactive effect was seen for SCE frequencies, in which increases attributable to smoking were similar in the worker and control groups.
对两组职业性接触铀的工人的血液淋巴细胞培养物进行了不对称染色体畸变和姐妹染色单体交换（SCE）检测。两个细胞遗传学终点均有显著增加。对于双着丝粒染色体，这似乎特别与可溶性铀的接触有关。这些男性所经历的外部辐射暴露不足以解释双着丝粒染色体的增加，并且内部沉积的铀对淋巴细胞的照射也会很少。由于SCE也有所增加，遗传毒性作用可能归因于该化合物的化学性质。与吸烟相关的双着丝粒染色体频率增加在接触可溶性铀的组中最为明显，表明这两种致断裂剂之间存在某种相互作用。在SCE频率方面未观察到这种相互作用效应，其中吸烟导致的增加在工人组和对照组中相似。
