Ganguly B B, Talukdar G, Sharma A
Department of Botany, University of Calcutta, India.
Mutat Res. 1992 Jun;282(2):61-7. doi: 10.1016/0165-7992(92)90075-s.
The comparative effects of inorganic and organic tin compounds on chromosomes were assessed in human peripheral blood lymphocytes of healthy donors 20-40 years of age. The endpoints observed were chromosomal abnormalities, sister-chromatid exchanges (SCEs) and cell cycle kinetics. The maximum concentrations which reduced the replicative index by about 50%, of stannic chloride and trimethyltin chloride were 40 micrograms and 2 micrograms per culture respectively. The tested doses were 20 micrograms and 10 micrograms of stannic chloride and 1 microgram and 0.5 microgram of trimethyltin chloride. Both doses of stannic chloride induced a much higher frequency of chromosomal abnormalities (P less than 0.05-P less than 0.001) and a greater reduction of cell cycle kinetics than the corresponding relative doses of trimethyltin chloride. The frequencies of SCEs/cell induced by the latter were, however, slightly higher than those induced by the former.
在20至40岁健康供体的人外周血淋巴细胞中评估了无机锡化合物和有机锡化合物对染色体的比较效应。观察的终点是染色体异常、姐妹染色单体交换（SCE）和细胞周期动力学。使复制指数降低约50%的氯化锡和三甲基氯化锡的最大浓度分别为每培养物40微克和2微克。测试剂量为20微克和10微克氯化锡以及1微克和0.5微克三甲基氯化锡。与相应相对剂量的三甲基氯化锡相比，两种剂量的氯化锡均诱导出更高频率的染色体异常（P小于0.05 - P小于0.001），并且细胞周期动力学的降低幅度更大。然而，后者诱导的SCEs/细胞频率略高于前者。
