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Cell division, chromosomal aberration, and micronuclei formation in human peripheral blood lymphocytes. Effect of stannic chloride on donor's age.

作者信息

Ganguly B B

机构信息

Biochemistry Unit, Indian Statistical Institute, Calcutta.

出版信息

Biol Trace Elem Res. 1993 Jul;38(1):55-62. doi: 10.1007/BF02783982.

DOI:10.1007/BF02783982
PMID:7691132
Abstract

Age related cytotoxicity of stannic chloride was evaluated in human lymphocytes considering mitotic index (MI), damaged cell (DC), chromosome aberration (CA), and micronuclei formation (MNC) as endpoints. Significant elevation of DCs, CAs, MNCs, and reduction of MI were observed in all classified age groups compared to each control set. The mean frequencies of abnormalities show a statistically significant increase with subject's age. Linearity of the effect of age was common for both untreated and treated lymphocytes of both sexes.

摘要

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本文引用的文献

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The effect of tin chloride on the structure and function of DNA in human white blood cells.氯化亚锡对人白细胞中DNA结构和功能的影响。
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Effects of stannic chloride on human leucocytes in vitro.四氯化锡对人白细胞的体外作用。
Cytobios. 1988;56(224):23-7.
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Cytotoxic effects of trimethyltin chloride on human peripheral blood lymphocytes in vitro.三甲基氯化锡对人外周血淋巴细胞的体外细胞毒性作用。
Hum Toxicol. 1989 Sep;8(5):349-53. doi: 10.1177/096032718900800503.
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Chromosomal aberration and sister-chromatid exchange frequencies in peripheral blood lymphocytes of a large human population sample. II. Extension of age range.大量人群样本外周血淋巴细胞中的染色体畸变及姐妹染色单体交换频率。II. 年龄范围的扩展
Mutat Res. 1989 Jun;212(2):149-54. doi: 10.1016/0027-5107(89)90065-1.
10
Frequency of micronuclei induced in peripheral lymphocytes by trimethyltin chloride.三甲基氯化锡诱导外周血淋巴细胞产生微核的频率。
Mutat Res. 1990 Sep;245(1):33-9. doi: 10.1016/0165-7992(90)90022-c.