Moroni F, Fantozzi R, Masini E, Mannaioni P F
Eur J Pharmacol. 1977 Jan 7;41(1):59-63. doi: 10.1016/0014-2999(77)90371-5.
The influence of serotonin and catecholamines on the uptake and metabolism of 14C-histamine by isolated guinea pig atrium has been investigated. Epinephrine, norepinephrine and serotonin were found to reduce the histamine uptake and the formation of methylhistamine, in a dose-dependent fashion. The order of potency was epinephrine greater than norepinephrine greater than serotonin. Aliphatic diamines, such as spermine, do not affect the accumulation and metabolism of histamine. It is suggested that serotonin and catecholamines, may enhance histamine responses by decreasing the uptake and metabolism of this amine.
研究了血清素和儿茶酚胺对离体豚鼠心房摄取和代谢14C-组胺的影响。发现肾上腺素、去甲肾上腺素和血清素以剂量依赖的方式降低组胺摄取和甲基组胺的形成。效力顺序为肾上腺素大于去甲肾上腺素大于血清素。脂肪族二胺，如精胺，不影响组胺的积累和代谢。提示血清素和儿茶酚胺可能通过减少这种胺的摄取和代谢来增强组胺反应。
