在体外实验中，甲硫咪胺对豚鼠心房和小鼠肿瘤性肥大细胞中组胺摄取及代谢的抑制作用。
The inhibition of histamine uptake and metabolism by burimamide in the guinea-pig atrium and in mouse neoplastic mast cells, in vitro.
作者信息
Fantozzi R, Mannaioni P F, Moroni F
出版信息
Br J Pharmacol. 1973 Oct;49(2):361-3. doi: 10.1111/j.1476-5381.1973.tb08384.x.
Abstract
Burimamide, an H(2)-receptor blocking agent, has been shown capable of blocking the uptake and metabolism of [(14)C]-histamine, both in the guinea-pig isolated atrium and in murine neoplastic mast cells. This occurs even at concentrations far below the dose range capable of blocking the positive chronotropic effect of histamine in the isolated atrium. In the atrium, very low concentrations of burimamide were found capable of blocking histamine metabolism.
摘要
甲氰咪胺，一种H₂受体阻断剂，已被证明在豚鼠离体心房和小鼠肿瘤性肥大细胞中均能阻断[¹⁴C]组胺的摄取和代谢。即使在远低于能阻断组胺对离体心房正性变时作用的剂量范围内的浓度下，这种情况也会发生。在心房中，发现极低浓度的甲氰咪胺就能阻断组胺代谢。
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