大鼠肝脏细胞色素P-450加氧酶对9,10-二甲基-1,2-苯并蒽的跨环双加氧作用。
Transannular dioxygenation of 9,10-dimethyl-1,2-benzanthracene by cytochrome P-450 oxygenase of rat liver.
作者信息
Chen C, Tu M
出版信息
Biochem J. 1976 Dec 15;160(3):805-8. doi: 10.1042/bj1600805.
Abstract
9,10-Dimethyl-1,2-benzanthracene is oxygenated by rat liver microsomal cytochrome P-450 oxygenase to its 9,10-epidioxide. This transannular 1,4-peroxide is converted further into the diol by the microsomal preparation and NADPH. These two products constitute the majority of the metabolites found under the conditions described.
摘要
9,10-二甲基-1,2-苯并蒽被大鼠肝脏微粒体细胞色素P-450加氧酶氧化为其9,10-环氧化物。这种跨环1,4-过氧化物通过微粒体制剂和NADPH进一步转化为二醇。在所述条件下发现的代谢产物中，这两种产物占了大部分。
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