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大鼠肝脏微粒体制剂对二叔丁基对甲酚的环羟基化作用。

Ring hydroxylation of di-t-butylhydroxytoluene by rat liver microsomal preparations.

作者信息

Shaw Y S, Chen C

出版信息

Biochem J. 1972 Aug;128(5):1285-91. doi: 10.1042/bj1281285.

DOI:10.1042/bj1281285
PMID:4404965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1174016/
Abstract

3,5-Di-t-butylhydroxytoluene (compound I) was converted into 4-hydroperoxy-4-methyl-2,6-di-t-butylcyclohexa-2,5-dienone (compound II), 4-hydroxy-4-methyl-2,6-di-t-butylcyclohexa-2,5-dienone (compound III) and 2,6-di-t-butyl-4-hydroxymethylphenol (compound IV) by rat liver microsomal preparations in the presence of NADPH and air. The oxidation of compound (I) by m-chloroperbenzoic acid also produced the same compounds. These results suggest that hydroperoxide can be an intermediate in aromatic hydroxylation and that biological oxygenations resemble per-acid reactions.

摘要

在存在烟酰胺腺嘌呤二核苷酸磷酸（NADPH）和空气的情况下，大鼠肝脏微粒体制剂将3,5-二叔丁基羟基甲苯（化合物I）转化为4-氢过氧-4-甲基-2,6-二叔丁基环己-2,5-二烯酮（化合物II）、4-羟基-4-甲基-2,6-二叔丁基环己-2,5-二烯酮（化合物III）和2,6-二叔丁基-4-羟甲基苯酚（化合物IV）。间氯过氧苯甲酸对化合物（I）的氧化也产生了相同的化合物。这些结果表明，氢过氧化物可能是芳香族羟基化反应中的中间体，并且生物氧化反应类似于过酸反应。

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本文引用的文献

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