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Metabolic pathways of 7,12-dimethylbenz[a]anthracene in hepatic microsomes.
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2
The formation of dihydrodiols by the chemical or enzymic oxidation of benz[a] anthracene and 7,12-dimethylbenz[a] anthracene.
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The formation of dihydrodiols by the chemical or enzymic oxidation of 7-hydroxymethyl-12-methylbenz[alpha]anthracene and the possible role of hydroxymethyl dihydrodiols in the metabolic activation of 7,12-dimethylbenz[alpha]anthracene.
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Identification of four trans-3,4-dihydrodiol metabolites of 7,12-dimethylbenz[a]anthracene and their in vitro DNA-binding activities upon further metabolism.
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Comparison of metabolism-mediated binding to DNA of 7-hydroxymethyl-12-methylbenz(a)anthracene and 7, 12-dimethylbenz(a)anthracene.
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Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation and metabolism of epoxides related to 7,12-dimethylbenz(a)anthracene.
Biochem J. 1973 Feb;131(2):405-13. doi: 10.1042/bj1310405.
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Stereoselectivity of rat liver cytochrome P-450 isozymes: direct determination of enantiomeric composition of K-region epoxides formed in the metabolism of benz[a]anthracene and 7,12-dimethylbenz[a]anthracene.
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Combined reversed-phase and normal-phase high-performance liquid chromatography in the purification and identification of 7,12-dimethylbenz[a]anthracene metabolites.
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Metabolism of 6-methylbenz[a]anthracene by rat liver microsomes and mutagenicity of metabolites.
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引用本文的文献
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Lipidomic Profile and Enzymes Activity in Hepatic Microsomes of Rats in Physiological and Pathological Conditions.
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Hepatic dysfunction induced by 7, 12-dimethylbenz(α)anthracene and its obviation with erucin using enzymatic and histological changes as indicators.
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Evaluation of protective effect of myricetin, a bioflavonoid in dimethyl benzanthracene-induced breast cancer in female Wistar rats.
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Diminution of hepatic response to 7, 12-dimethylbenz(α)anthracene by ethyl acetate fraction of Acacia catechu willd. through modulation of xenobiotic and anti-oxidative enzymes in rats.
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Metabolism of 7,12,-dimethylbenz(a)anthracene by normal and regenerating rat livers.
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Identification of 7,12-dimethylbenz[a]anthracene metabolites that lead to mutagenesis in mammalian cells.
Proc Natl Acad Sci U S A. 1979 Feb;76(2):862-6. doi: 10.1073/pnas.76.2.862.
7
Identification of four trans-3,4-dihydrodiol metabolites of 7,12-dimethylbenz[a]anthracene and their in vitro DNA-binding activities upon further metabolism.
Proc Natl Acad Sci U S A. 1978 Nov;75(11):5466-70. doi: 10.1073/pnas.75.11.5466.
8
Structural analysis as a means of predicting carcinogenic potential.
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本文引用的文献
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Selective adrenal necrosis and apoplexy induced by 7, 12-dimethylbenz(a)anthracene.
J Exp Med. 1961 Nov 1;114(5):741-60. doi: 10.1084/jem.114.5.741.
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METABOLISM OF POLYCYCLIC COMPOUNDS. THE METABOLISM OF 7,12-DIMETHYLBENZ(ALPHA)ANTHRACENE BY RAT-LIVER HOMOGENATES.
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INDUCED PROTECTION OF ADRENAL CORTEX AGAINST 7,12-DIMETHYLBENZ(ALPHA)ANTHRACENE. INFLUENCE OF ETHIONINE. INDUCTION OF MENADIONE REDUCTASE. INCORPORATION OF THYMIDINE-H3.
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Mammary cancer induced by a single feeding of polymucular hydrocarbons, and its suppression.
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Synthesis of metabolites of 7,12-dimethylbenz[a]anthracene. 4-Hydroxy-7,12-dimethylbenz[a]anthracene, 7-hydroxymethyl-12-methylbenz[a]anthracene, their methyl ethers, and acetoxy derivatives.
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The effect of pretreatment with adrenal-protecting compounds on the metabolism of 7,12-dimethylbenz[a]anthracene and related compounds by rat-liver homogenates.
Biochem J. 1967 Aug;104(2):394-403. doi: 10.1042/bj1040394.
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Induction of adrenal damage and cancer with metabolites of 7,12-dimethylbenz(a)anthracene.
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Quantitative aspects of the metabolism of 7, 12-dimethylbenz[a]anthracene by liver homogenates from animals of different age, sex and species.
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The metabolism of 7- and 12-methylbenz[a]anthracene and their derivatives.
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Studies on the metabolism of 7-methylbenz-[a]anthracene and 7,12-dimethylbenz[1]anthracene and its hydroxymethyl derivatives in rat liver and adrenal homogenates.
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