Miyamoto A, Kobayashi T, Kawaguchi H, Ando J, Yasdu H
Hokkaido Igaku Zasshi. 1976 Sep;51(5):409-14.
This study was aimed to evaluate the noninvasive method of radioisotopic angiocardiography for detecting a disproportionate thickning of the interventricular septum relative to the left ventricular free wall in the patient with idiopathic hypertrophic cardiomyopathy. The experimental study was performed to compare the imaged size of myocardial wall obtained my filling up with technetium 99 m labeled sponge in biventricular cavities, with the actually measured thickness of the heart specimen. The resultant correlation between actual and imaged size of the left ventricular wall was excellent (r = 0.95). In the clinical application of this method, a gated cardiac blood pool scan was performed after the intravenous administration of technetium 99 m labeled human serum albumin in a dose of 10 mCi. The cardiac images were obtained in anterior, 30, 35, 40 and 45 degree left anterior oblique projection, and evaluated by visual inspection and semi-quantitatively by tracing the myocardial borders. As a result, the imaged asymmetric septal hypertrophy was evident in all four patients with PMD, with a ratio of septum to left ventricular free wall of 1.35 compared to 0.76 in five patients with left ventricular hypertrophy of known heart disease, and 0.88 in twenty-one miscellaneous cardiac patients without left ventricular hypertrophy. Thus, RI angiocardiography provides a safe, repeatable method for detection and evaluation of Primary Myocardial Disease.
本研究旨在评估放射性核素心血管造影术这种非侵入性方法，以检测特发性肥厚型心肌病患者室间隔相对于左心室游离壁的不成比例增厚情况。进行了一项实验研究，通过用锝99m标记的海绵填充双心室腔来比较所获得的心肌壁成像大小与心脏标本的实际测量厚度。左心室壁实际大小与成像大小之间的相关性极佳（r = 0.95）。在该方法的临床应用中，静脉注射10毫居里的锝99m标记人血清白蛋白后进行门控心血池扫描。在前后位、左前斜30度、35度、40度和45度投影下获取心脏图像，并通过目视检查和追踪心肌边界进行半定量评估。结果，在所有4例原发性心肌病患者中均明显可见成像的不对称性室间隔肥厚，室间隔与左心室游离壁的比值为1.35，而在5例已知心脏病的左心室肥厚患者中该比值为0.76，在21例无左心室肥厚的其他心脏病患者中该比值为0.88。因此，放射性核素心血管造影术为原发性心肌病的检测和评估提供了一种安全、可重复的方法。
