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逆转录后通过聚合酶链反应对胃癌中c-erbB-2 mRNA表达进行特异性检测。

Specific detection of c-erbB-2 mRNA expression in gastric cancers by the polymerase chain reaction following reverse transcription.

作者信息

Ninomiya I, Endo Y, Yonemura Y, Noguchi M, Fushida S, Nakai M, Takamura H, Harada F, Suzuki T, Miyazaki I

机构信息

Department of Surgery II, School of Medicine, Kanazawa University, Japan.

出版信息

Br J Cancer. 1992 Jul;66(1):84-7. doi: 10.1038/bjc.1992.221.

DOI:10.1038/bjc.1992.221
PMID:1379062
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1977918/
Abstract

The expression of the c-erbB-2 mRNA in human embryonic lung fibroblasts, a gastric cancer cell line, mature placenta, and 25 gastric cancer tissues was examined by using the polymerase chain reaction following reverse transcription. This technique can be used to examine c-erbB-2 mRNA expression in a small endoscopic biopsy specimen before surgery.

摘要

采用逆转录后的聚合酶链反应检测人胚肺成纤维细胞、一种胃癌细胞系、成熟胎盘以及25例胃癌组织中c-erbB-2 mRNA的表达。该技术可用于在手术前检测小的内镜活检标本中c-erbB-2 mRNA的表达。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/1977918/04790764ef78/brjcancer00059-0088-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/1977918/09fe5f6f13fd/brjcancer00059-0087-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/1977918/04790764ef78/brjcancer00059-0088-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/1977918/09fe5f6f13fd/brjcancer00059-0087-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/1977918/04790764ef78/brjcancer00059-0088-a.jpg

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本文引用的文献

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Science. 1988 Aug 5;241(4866):708-12. doi: 10.1126/science.3041594.
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Nature. 1986;319(6050):230-4. doi: 10.1038/319230a0.
8
Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.与表皮生长因子受体具有广泛同源性的酪氨酸激酶受体与neu癌基因位于同一染色体位置。
Science. 1985 Dec 6;230(4730):1132-9. doi: 10.1126/science.2999974.
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A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.一种与v-erbB相关的原癌基因c-erbB-2，不同于c-erbB-1/表皮生长因子受体基因，在一种人涎腺腺癌中发生扩增。
Proc Natl Acad Sci U S A. 1985 Oct;82(19):6497-501. doi: 10.1073/pnas.82.19.6497.
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