韩国普通人群142人的姐妹染色单体交换基线频率。

Baseline frequency of sister-chromatid exchanges in 142 persons of the general Korean population.

作者信息

Park E H, Kim Y J, Byun D H, Lee J Y, Lee J S

机构信息

Department of Biology, College of Natural Sciences, Hanyang University, Seoul, South Korea.

出版信息

Mutat Res. 1992 Aug;268(2):239-46. doi: 10.1016/0027-5107(92)90230-y.

DOI:10.1016/0027-5107(92)90230-y

PMID:1379330

Abstract

Baseline frequencies of sister-chromatid exchange (SCE) were measured in lymphocytes of 142 healthy Koreans ranging in age from newborn infants to the fifties. The overall mean frequency of SCE was 8.78 +/- 0.24/cell. However, highly significant differences were found between individuals. The mean SCE values of the newborn babies and small children less than 10 years old were significantly lower than those of other age groups. No age effect was, however, observed in adolescent and adult subjects. Females had statistically higher SCE levels than males. The mean SCE frequencies of smokers, measured in male subjects more than 10 years old, were slightly, but statistically significantly, higher than those of non-smokers.

摘要

在142名年龄从新生儿到五十多岁的健康韩国人的淋巴细胞中测量了姐妹染色单体交换（SCE）的基线频率。SCE的总体平均频率为8.78±0.24/细胞。然而，个体之间存在高度显著差异。新生儿和10岁以下儿童的SCE平均值显著低于其他年龄组。然而，在青少年和成年受试者中未观察到年龄效应。女性的SCE水平在统计学上高于男性。在10岁以上男性受试者中测量的吸烟者的平均SCE频率略高于非吸烟者，但在统计学上有显著差异。